Endomembrane targeting of human OAS1 p46 augments antiviral activity.

doi:10.7554/eLife.71047

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Article

Endomembrane targeting of human OAS1 p46 augments antiviral activity.

eLife - 3 Aug 2021

Soveg Frank W, Schwerk Johannes, Gokhale Nandan S, Cerosaletti Karen, Smith Julian R, Pairo-Castineira Erola, Kell Alison M, Forero Adriana, Zaver Shivam A, Esser-Nobis Katharina, Roby Justin A, Hsiang Tien-Ying, Ozarkar Snehal, Clingan Jonathan M, McAnarney Eileen T, Stone Amy El, Malhotra Uma, Speake Cate, Perez Joseph, Balu Chiraag, Allenspach Eric J, Hyde Jennifer L, Menachery Vineet D, Sarkar Saumendra N, Woodward Joshua J, Stetson Daniel B, Baillie John Kenneth, Buckner Jane H, Gale Michael, Savan Ram

Abstract excerpt

Many host RNA sensors are positioned in the cytosol to detect viral RNA during infection. However, most positive-strand RNA viruses replicate within a modified organelle co-opted from intracellular membranes of the endomembrane system, which shields viral products from cellular innate immune sensors. Targeting innate RNA sensors to the endomembrane system may enhance their ability to sense RNA generated by...

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PMID: 34342578
DOI: 10.7554/eLife.71047
PMCID: PMC8357416

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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