Article

ADA2 is a lysosomal DNase regulating the type-I interferon response

2020-06-21

Abstract excerpt

Deficiency of adenosine deaminase 2 (DADA2) is a severe, congenital syndrome, which manifests with hematologic, immunologic and inflammatory pathologies. DADA2 is caused by biallelic mutations in ADA2 , but the function of ADA2, and the mechanistic link between ADA2 deficiency and the severe inflammatory phenotype remains unclear. Here, we show that monocyte-derived proteomes from DADA2 patients are highly enrich...

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Literature Corpus work: 467c372d-485e-5529-905b-300b539f45d1
DOI: 10.1101/2020.06.21.162990

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