Article

SARS-CoV-2 5’-UTR stem-loops activate the antiviral protein oligoadenylate synthetase 1 (OAS1)

2026-04-02

Abstract excerpt

The innate immune system relies on pathogen recognition receptors, such as the 2’,5’-oligoadenylate synthetase (OAS) proteins, to detect pathogen-associated molecular patterns like viral double-stranded (ds)RNA. A specific splicing variant of OAS1 (OAS1-p46) has been implicated in initiating an immune response that leads to decreased disease severity during SARS-CoV-2 infection. OAS1-p46 has a C-terminal lipid mod...

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Literature Corpus work: 3690cf05-226b-5977-829b-0dd099a116a0
DOI: 10.64898/2026.04.01.715984

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