Article

Endomembrane targeting of human OAS1 p46 augments antiviral activity

2021-04-22

Abstract excerpt

<h4>SUMMARY</h4> Many host RNA sensors are positioned in the cytosol to detect viral RNA during infection. However, most positive-strand RNA viruses replicate within a modified organelle co-opted from intracellular membranes of the endomembrane system, which shields viral products from host cell innate immune sensors. Targeting innate RNA sensors to the endomembrane system may enhance their ability to sense viral...

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Literature Corpus work: 2b6e6c91-b8f3-53f0-84eb-c8eae689598d
DOI: 10.1101/2021.04.21.440697

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