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A non-canonical role for the ATAD2 ortholog BDF7 in nucleolar ribosome maturation and amastigote survival in <i>Leishmania mexicana</i>

2025-12-25

Abstract excerpt

ATAD2 is a widely conserved, homohexameric ATPase that, in humans, features a bromodomain tier. It plays a role in chromatin remodelling in embryonic stem and germ cells but is frequently upregulated in many cancers, making its bromodomain an attractive drug target. While ATAD2-like proteins generally modulate nucleosome density to control genome compartmentalization and gene expression across eukaryotes, their pr...

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Identifiers and source

Literature Corpus work
656a891a-3480-5015-bc6b-053f51b1b899
DOI
10.64898/2025.12.23.692120
Open publication

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A non-canonical role for the ATAD2 ortholog BDF7 in nucleolar ribosome maturation and amastigote survival in <i>Leishmania mexicana</i>DOI 10.64898/2025.12.23.692120
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