Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct Antiviral Roles for Human 2′,5′-Oligoadenylate Synthetase Family Members against Dengue Virus Infection

18 Nov 2009

Abstract excerpt

The 2',5'-oligoadenylate synthetase (OAS) and its downstream effector RNase L play important roles in host defense against virus infection. Oas1b, one of the eight Oas1 genes in the mouse genome, has been identified as a murine flavivirus-resistance gene. Four genes, OAS1, OAS2, OAS3, and OAS-like (OASL), have been identified in the human OAS gene family, and 10 isoforms, including OAS1 (p42, p44, p46, p48, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV Research and Treatment
Share to Mosquito-borne diseases and control
Share to Viral Infections and Vectors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19923450
DOI: 10.4049/jimmunol.0902728

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct Antiviral Roles for Human 2′,5′-Oligoadenylate Synthetase Family Members against Dengue Virus InfectionPMID 19923450Read ↗

Oligoadenylate synthase-like (OASL) proteins: dual functions and associations with diseases.Semantic proximity Read ↗

RNA regulation of the antiviral protein 2′‐5′‐oligoadenylate synthetaseSemantic proximity Read ↗

Innate resistance to flavivirus infections and the functions of 2'-5' oligoadenylate synthetases.Semantic proximity Read ↗

Genomic Structure of the Mouse 2',5'-Oligoadenylate Synthetase Gene FamilySemantic proximity Read ↗

Porcine 2′, 5′‐oligoadenylate synthetases inhibit Japanese encephalitis virus replication in vitroSemantic proximity Read ↗

The chicken 2'-5' oligoadenylate synthetase A inhibits the replication of West Nile VirusSemantic proximity Read ↗

Polymorphisms in the oligoadenylate synthetase gene cluster and its association with clinical outcomes of dengue virus infection.Semantic proximity Read ↗

Variation in antiviral 2',5'-oligoadenylate synthetase (2'5'AS) enzyme activity is controlled by a single-nucleotide polymorphism at a splice-acceptor site in the OAS1 gene.Semantic proximity Read ↗

Association of dengue virus infection susceptibility with polymorphisms of 2'-5'-oligoadenylate synthetase genes: a case-control study.Semantic proximity Read ↗

The large form of human 2′,5′-Oligoadenylate Synthetase (OAS3) exerts antiviral effect against Chikungunya virusSemantic proximity Read ↗

Characterization of the 2'-5'-oligoadenylate synthetase ubiquitin-like familySemantic proximity Read ↗

Antagonism of the Interferon-Induced OAS-RNase L Pathway by Murine Coronavirus ns2 Protein Is Required for Virus Replication and Liver PathologySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.