Article

Alternative splicing broadens antiviral diversity at the human <i>OAS2</i> locus

2025-02-24

Abstract excerpt

Interferons (IFN) are cytokines that regulate the expression of hundreds of genes during viral infections to generate a broadly antiviral environment in the stimulated cell. Antiviral breadth is provided by the concurrent expression of many individual IFN-stimulated genes (ISG), each encoding a protein with often exquisite antiviral specificity. Here, we show that mechanistic plasticity at a single genetic locus i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0e643fee-5ad6-53ba-8a06-6ec8aac2bcc4
DOI: 10.1101/2025.02.24.639105

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Alternative splicing broadens antiviral diversity at the human <i>OAS2</i> locusDOI 10.1101/2025.02.24.639105Read

SARS-CoV-2 selectively induces the expression of unproductive splicing isoforms of interferon, class I MHC and splicing machinery genesSemantic proximity Read

SARS-CoV-2 Selectively Induces the Expression of Unproductive Splicing Isoforms of Interferon, Class I MHC, and Splicing Machinery GenesSemantic proximity Read

Multiple layers of innate immune response antagonism of SARS-CoV-2Semantic proximity Read

Oligoadenylate synthase-like (OASL) proteins: dual functions and associations with diseases.Semantic proximity Read

Switching of OAS1 splicing isoforms mitigates SARS-CoV-2 infectionSemantic proximity Read

Variant- and Vaccination-Specific Alternative Splicing Profiles in SARS-CoV-2 InfectionsSemantic proximity Read

SARS-CoV-2-Encoded MiRNAs Inhibit Host Type I Interferon Pathway and Mediate Allelic Differential Expression of Susceptible Gene.Semantic proximity Read

Broad-spectrum RNA antiviral inspired by ISG15 <sup>-/-</sup> deficiencySemantic proximity Read

Redundant and distinct mechanisms suppress innate immune activation during SARS-CoV-2 infection.Semantic proximity Read

A novel <i>ISG15</i> transcript restricts influenza A virus infectionSemantic proximity Read

Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2Semantic proximity Read

RNA regulation of the antiviral protein 2′‐5′‐oligoadenylate synthetaseSemantic proximity Read