Article

The Alzheimer’s disease risk gene BIN1 modulates neural network activity via the regulation of L-type calcium channel expression in human-induced neurons

2022-01-20

Abstract excerpt

<h4>Background</h4> Bridging Integrator 1 ( BIN1 ) is the second most important Alzheimer’s disease (AD) risk gene, but its physiological roles in neurons and its contribution to brain pathology remain largely elusive. In this work, we show that BIN1 plays a critical role in the regulation of calcium homeostasis, electrical activity, and gene expression of glutamatergic neurons. <h4>Methods</h4> We generated 3...

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Literature Corpus work: cfc5bd5d-7b63-5bcf-aee2-65d07a57edb8
DOI: 10.1101/2022.01.18.476601

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