Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alzheimer’s disease risk gene BIN1 induces Tau-dependent network hyperexcitability

13 Jul 2020

Abstract excerpt

Genome-wide association studies identified the BIN1 locus as a leading modulator of genetic risk in Alzheimer’s disease (AD). One limitation in understanding BIN1 ’s contribution to AD is its unknown function in the brain. AD-associated BIN1 variants are generally noncoding and likely change expression. Here, we determined the effects of increasing expression of the major neuronal isoform of human BIN1 in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Mitochondrial Function and Pathology
Share to Neuroscience and Neuropharmacology Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32657270
DOI: 10.7554/elife.57354

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alzheimer’s disease risk gene BIN1 induces Tau-dependent network hyperexcitabilityPMID 32657270Read ↗

Alzheimer’s disease risk gene <i>BIN1</i> induces Tau-dependent network hyperexcitabilitySemantic proximity Read ↗

The Alzheimer’s disease risk gene BIN1 modulates neural network activity via the regulation of L-type calcium channel expression in human-induced neuronsSemantic proximity Read ↗

The Alzheimer’s disease risk gene BIN1 regulates activity-dependent gene expression in human-induced glutamatergic neuronsSemantic proximity Read ↗

Alzheimer’s genetic risk factor Bin1 controls synapse vesicle exo-endocytosis in inhibitory synapsesSemantic proximity Read ↗

Cell-autonomous and non-cell autonomous effects of neuronal BIN1 loss in vivoSemantic proximity Read ↗

Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology.Semantic proximity Read ↗

A polymorphism in the BIN1 gene influences its expression and is associated with the risk of Alzheimer's disease: An integrated analysis.Semantic proximity Read ↗

Bridging Integrator 1 (BIN1) Protein Expression Increases in the Alzheimer's Disease Brain and Correlates with Neurofibrillary Tangle PathologySemantic proximity Read ↗

BIN1 expression in the presynaptic compartment leads to isoform-specific synaptotoxicitySemantic proximity Read ↗

Bridging integrator 1 protein loss in Alzheimer’s disease promotes synaptic tau accumulation and disrupts tau releaseSemantic proximity Read ↗

Bridging Integrator 1 (BIN1) Genotypes Mediate Alzheimer's Disease Risk by Altering Neuronal Degeneration.Semantic proximity Read ↗

The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memorySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.