Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Mechanistic Role of Bridging Integrator 1 (BIN1) in Alzheimer's Disease.

Cellular and molecular neurobiology - 1 Oct 2021

Gao Peirong, Ye Lingqi, Cheng Hongrong, Li Honglei

Abstract excerpt

Alzheimer's disease (AD) is the leading cause of dementia. The majority of AD cases are late-onset, multifactorial cases. Genome-wide association studies have identified more than 30 loci associated with sporadic AD (SAD), one of which is Bridging integrator 1 (BIN1). For the past few years, there has been a consensus that BIN1 is second only to APOE as the strongest genetic risk factor for SAD. Therefore, many...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Alzheimer Disease
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nuclear Proteins

Share to tau Proteins

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 32719966
DOI: 10.1007/s10571-020-00926-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Mechanistic Role of Bridging Integrator 1 (BIN1) in Alzheimer's Disease.PMID 32719966Read ↗

Bridging integrator 1 (BIN1): form, function, and Alzheimer's disease.Semantic proximity Read ↗

Bridging Integrator 1 (BIN1) Protein Expression Increases in the Alzheimer's Disease Brain and Correlates with Neurofibrillary Tangle PathologySemantic proximity Read ↗

Bridging Integrator 1 (BIN1) Genotypes Mediate Alzheimer's Disease Risk by Altering Neuronal Degeneration.Semantic proximity Read ↗

The bridging integrator 1 Gene rs7561528 polymorphism contributes to Alzheimer's disease susceptibility in East Asian and Caucasian populations.Semantic proximity Read ↗

BIN1 Is Decreased in Sporadic but Not Familial Alzheimer’s Disease or in AgingSemantic proximity Read ↗

Common variants at Bin1 are associated with sporadic Alzheimer's disease in the Han Chinese population.Semantic proximity Read ↗

[BIN1 (amphiphysin 2) in the pathogenesis of cognitive impairment].Semantic proximity Read ↗

Aberrant accrual of BIN1 near Alzheimer’s disease amyloid deposits in transgenic modelsSemantic proximity Read ↗

New Insights on Bridging Integrator 1 Protein Isoforms as a Risk Increasing Gene in Alzheimer’s DiseaseSemantic proximity Read ↗

Association between methylation of BIN1 promoter in peripheral blood and preclinical Alzheimer’s diseaseSemantic proximity Read ↗

Genetic variation in BIN1 gene and Alzheimer's disease risk in Han Chinese individuals.Semantic proximity Read ↗

sTREM2 Mediates the Correlation Between BIN1 Gene Polymorphism and Tau Pathology in Alzheimer's Disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.