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New Insights on Bridging Integrator 1 Protein Isoforms as a Risk Increasing Gene in Alzheimer’s Disease

2025-04-03

Abstract excerpt

<h4>INTRODUCTION</h4> Genome-wide association studies (GWAS) have identified Bridging Integrator 1 ( BIN1 ) as the second-most significant genetic risk factor for Alzheimer’s disease (AD). We performed GWAS by proxy (GWAX) using UKBiobank and replicated this finding. However, the mechanism by which BIN1 impacts AD risk is largely unknown. <h4>METHODS</h4> To address this, we first measured the expression of...

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Literature Corpus work: 394a0f46-b7e4-5cdc-8671-36d080de061c
DOI: 10.1101/2025.03.31.646439

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