Article

Alzheimer’s disease risk gene <i>BIN1</i> induces Tau-dependent network hyperexcitability

2020-03-30

Abstract excerpt

Genome-wide association studies identified the BIN1 locus as a leading modulator of genetic risk in Alzheimer’s disease (AD). One limitation in understanding BIN1 ’s contribution to AD is its unknown function in the brain. AD-associated BIN1 variants are generally noncoding and likely change expression. Here, we determined the effects of increasing expression of the major neuronal isoform of human BIN1 in cultu...

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Literature Corpus work: 142c59c7-0dcd-5f0b-b366-53d6952e6149
DOI: 10.1101/2020.03.29.014720

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