Article

The Alzheimer’s disease risk gene BIN1 regulates activity-dependent gene expression in human-induced glutamatergic neurons

2023-06-15

Abstract excerpt

<title>Abstract</title> Bridging Integrator 1 (BIN1) is the second most important Alzheimer’s disease (AD) risk gene, but its physiological roles in neurons and its contribution to brain pathology remain largely elusive. In this work, we show that BIN1 plays a critical role in the regulation of calcium homeostasis, electrical activity, and gene expression of glutamatergic neurons. Using single-cell RNA-sequenc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 135e73d3-cb19-5c09-a342-cf54937dd334
DOI: 10.21203/rs.3.rs-3017048/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Alzheimer’s disease risk gene BIN1 regulates activity-dependent gene expression in human-induced glutamatergic neuronsDOI 10.21203/rs.3.rs-3017048/v1Read

The Alzheimer’s disease risk gene BIN1 modulates neural network activity via the regulation of L-type calcium channel expression in human-induced neuronsSemantic proximity Read

Alzheimer’s disease risk gene BIN1 induces Tau-dependent network hyperexcitabilitySemantic proximity Read

Alzheimer’s disease risk gene BIN1 induces Tau-dependent network hyperexcitabilitySemantic proximity Read

New Insights on Bridging Integrator 1 Protein Isoforms as a Risk Increasing Gene in Alzheimer’s DiseaseSemantic proximity Read

Bridging integrator 1 (BIN1): form, function, and Alzheimer's disease.Semantic proximity Read

Interactome mapping in human excitatory neurons reveals novel risk genes and pathways in Alzheimer’s diseaseSemantic proximity Read

Convergent lines of evidence support BIN1 as a risk gene of Alzheimer's disease.Semantic proximity Read

The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defectsSemantic proximity Read

Alzheimer’s genetic risk factor Bin1 controls synapse vesicle exo-endocytosis in inhibitory synapsesSemantic proximity Read

The Mechanistic Role of Bridging Integrator 1 (BIN1) in Alzheimer's Disease.Semantic proximity Read

Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology.Semantic proximity Read

A polymorphism in the BIN1 gene influences its expression and is associated with the risk of Alzheimer's disease: An integrated analysis.Semantic proximity Read