Article

The Alzheimer susceptibility gene <i>BIN1</i> induces isoform-dependent neurotoxicity through early endosome defects

2021-04-04

Abstract excerpt

<h4>SUMMARY</h4> The Bridging Integrator 1 ( BIN1 ) gene is a major susceptibility gene for Alzheimer’s disease (AD). Deciphering its pathophysiological role is challenging due to its numerous isoforms. Here we observed in Drosophila that human BIN1 isoform1 (BIN1iso1) overexpression, contrary to BIN1iso8 and BIN1iso9, induced an accumulation of endosomal vesicles and neurodegeneration. Systematic search for en...

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Literature Corpus work: a8e4e506-2f9c-5fcb-9650-a3b0dc5b9e12
DOI: 10.1101/2021.04.02.438184

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