Article

Interactome mapping in human excitatory neurons reveals novel risk genes and pathways in Alzheimer’s disease

2026-03-16

Abstract excerpt

Alzheimer’s disease (AD) is an irreversible neurodegenerative disease defined by its molecular hallmarks - amyloid beta peptide plaques and neurofibrillary Tau tangles. Despite significant progress that has been made in uncovering a large number of genetic risk factors through extensive genomic sequencing and genetic studies, the molecular mechanisms driving AD-associated pathology and cognitive decline remain poo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f00f4ca2-1810-5d46-9121-5e15646ee773
DOI: 10.64898/2026.03.14.711835

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Interactome mapping in human excitatory neurons reveals novel risk genes and pathways in Alzheimer’s diseaseDOI 10.64898/2026.03.14.711835Read

Interactome mapping suggests new mechanistic details underlying Alzheimer's disease.Semantic proximity Read

Decoding cell-type-specific alterations in Alzheimer’s disease through scRNA-seq and network analysisSemantic proximity Read

RIN3 mutations impairing binding of the Alzheimer's disease-associated protein BIN1 lead to RAB5 hyperactivation and endosomal pathology.Semantic proximity Read

Proteomic characterization of the Alzheimer’s disease risk factor BIN1 interactomeSemantic proximity Read

Multiscale proteomic modeling reveals protein networks driving Alzheimer's disease pathogenesis.Semantic proximity Read

Upregulation of RIN3 induces endosomal dysfunction in Alzheimer’s diseaseSemantic proximity Read

Cell-type-specific Transcriptomic-wide Association Studies Detected 91 Independent Risk Genes for Alzheimer’s Disease DementiaSemantic proximity Read

Predictive Network Analysis Identifies <i>JMJD6</i> and Other Novel Key Drivers in Alzheimer’s DiseaseSemantic proximity Read

Integrative Multiomics Insights into the Genetic and Epigenetic Architecture of Alzheimer's Disease.Semantic proximity Read

Interaction studies of risk proteins in human induced neurons reveal convergent biology and novel mechanisms underlying autism spectrum disordersSemantic proximity Read

Identification of key genes and pathways for Alzheimer’s disease via combined analysis of genome-wide expression profiling in the hippocampusSemantic proximity Read

The Alzheimer's Cell Atlas (TACA): A single‐cell molecular map for translational therapeutics accelerator in Alzheimer's diseaseSemantic proximity Read