Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bridging integrator 1 (BIN1): form, function, and Alzheimer's disease.

Trends in molecular medicine - 1 Oct 2013

Tan Meng-Shan, Yu Jin-Tai, Tan Lan

Abstract excerpt

The bridging integrator 1 (BIN1) gene, also known as amphiphysin 2, has recently been identified as the most important risk locus for late onset Alzheimer's disease (LOAD), after apolipoprotein E (APOE). Here, we summarize the known functions of BIN1 and discuss the polymorphisms associated with LOAD, as well as their possible physiological effects. Emerging data suggest that BIN1 affects AD risk primarily by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Alzheimer Disease
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to BIN1 gene

Share to Genetic Predisposition to Disease

Share to Molecular Targeted Therapy

Share to Nerve Tissue Proteins

Share to Tauopathies

Source

Identifiers

PMID: 23871436
DOI: 10.1016/j.molmed.2013.06.004

Genes

BIN1
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bridging integrator 1 (BIN1): form, function, and Alzheimer's disease.PMID 23871436Read ↗

The Mechanistic Role of Bridging Integrator 1 (BIN1) in Alzheimer's Disease.Semantic proximity Read ↗

[BIN1 (amphiphysin 2) in the pathogenesis of cognitive impairment].Semantic proximity Read ↗

Bridging Integrator 1 (BIN1) Protein Expression Increases in the Alzheimer's Disease Brain and Correlates with Neurofibrillary Tangle PathologySemantic proximity Read ↗

Aberrant accrual of BIN1 near Alzheimer’s disease amyloid deposits in transgenic modelsSemantic proximity Read ↗

Genetic variation in BIN1 gene and Alzheimer's disease risk in Han Chinese individuals.Semantic proximity Read ↗

New Insights on Bridging Integrator 1 Protein Isoforms as a Risk Increasing Gene in Alzheimer’s DiseaseSemantic proximity Read ↗

Bridging Integrator 1 (BIN1) Genotypes Mediate Alzheimer's Disease Risk by Altering Neuronal Degeneration.Semantic proximity Read ↗

Alzheimer’s disease BIN1 coding variants increase intracellular Aβ by interfering with BACE1 recyclingSemantic proximity Read ↗

Association between methylation of BIN1 promoter in peripheral blood and preclinical Alzheimer’s diseaseSemantic proximity Read ↗

BIN1 Is Decreased in Sporadic but Not Familial Alzheimer’s Disease or in AgingSemantic proximity Read ↗

The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memorySemantic proximity Read ↗

BIN1 regulates BACE1 intracellular trafficking and amyloid-β productionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.