Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alzheimer’s genetic risk factor Bin1 controls synapse vesicle exo-endocytosis in inhibitory synapses

16 Jul 2025

Abstract excerpt

BIN1, a late-onset Alzheimer's disease (LOAD) risk gene, is an endocytic regulator with an unclear synaptic function. We find Bin1 more prominently in inhibitory synapses (vGAT positive) than in excitatory ones (vGLUT1 positive). Bin1 knockdown reduces inhibitory synapses independently of Aβ42 production, increasing GABA release from the remaining synapses due to accelerated vGAT exocytosis and endocytosis, which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Cellular transport and secretion
Share to Neuroscience and Neuropharmacology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40674214
DOI: 10.1016/j.celrep.2025.116005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alzheimer’s genetic risk factor Bin1 controls synapse vesicle exo-endocytosis in inhibitory synapsesPMID 40674214Read ↗

Alzheimer’s disease BIN1 coding variants increase intracellular Aβ by interfering with BACE1 recyclingSemantic proximity Read ↗

Alzheimer's disease BIN1 coding variants increase intracellular Aβ levels by interfering with BACE1 recycling.Semantic proximity Read ↗

BIN1 expression in the presynaptic compartment leads to isoform-specific synaptotoxicitySemantic proximity Read ↗

Aberrant accrual of BIN1 near Alzheimer’s disease amyloid deposits in transgenic modelsSemantic proximity Read ↗

Bridging integrator 1 protein loss in Alzheimer’s disease promotes synaptic tau accumulation and disrupts tau releaseSemantic proximity Read ↗

BIN1K358R suppresses glial response to plaques in mouse model of Alzheimer's diseaseSemantic proximity Read ↗

Alzheimer’s disease risk gene <i>BIN1</i> induces Tau-dependent network hyperexcitabilitySemantic proximity Read ↗

BIN1 regulates BACE1 intracellular trafficking and amyloid-β productionSemantic proximity Read ↗

The Alzheimer’s disease risk gene BIN1 regulates activity-dependent gene expression in human-induced glutamatergic neuronsSemantic proximity Read ↗

The Alzheimer’s disease risk gene BIN1 modulates neural network activity via the regulation of L-type calcium channel expression in human-induced neuronsSemantic proximity Read ↗

Alzheimer’s disease risk gene BIN1 induces Tau-dependent network hyperexcitabilitySemantic proximity Read ↗

Proteomic characterization of the Alzheimer’s disease risk factor BIN1 interactomeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.