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Article

Aberrant accrual of BIN1 near Alzheimer’s disease amyloid deposits in transgenic models

1 Dec 2018

Abstract excerpt

Bridging integrator 1 (BIN1) is the most significant late-onset Alzheimer's disease (AD) susceptibility locus identified via genome-wide association studies. BIN1 is an adaptor protein that regulates membrane dynamics in the context of endocytosis and membrane remodeling. An increase in BIN1 expression and changes in the relative levels of alternatively spliced BIN1 isoforms have been reported in the brains of...

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PMID: 30506549
DOI: 10.1111/bpa.12687

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