Article

BIN1 expression in the presynaptic compartment leads to isoform-specific synaptotoxicity

2025-08-15

Abstract excerpt

Alzheimer’s disease (AD) is characterized by a strong genetic predisposition and by an early loss of synaptic connectivity that strongly correlates with cognitive deficit. Some genetic determinants could contribute to synapse frailty toward AD pathology. However, the role of genetic determinants in AD pathogenesis remains poorly understood at the synaptic level. Here, we show that the expression of an isoform of t...

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Literature Corpus work: 7b6a6a89-d823-5c2a-8b3d-1d015a40137e
DOI: 10.1101/2025.08.11.669624

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