Back to search

Article

A Novel <i>C. elegans</i> Model for Tau Spreading Reveals Genes Critical for Endolysosomal Integrity and Seeded Tau Aggregation

2024-11-15

Abstract excerpt

The spreading of Tau pathology is closely associated with the progression of neurodegeneration and cognitive decline in Alzheimer’s disease and other tauopathies. A key event in this process is the rupture of endolysosomal vesicles following the intercellular transfer of Tau aggregates, releasing the transferred Tau species into the cytosol where they can promote the aggregation of endogenous Tau. However, underst...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
cf63d4ef-9561-5f9b-8659-3c2a28c6df6f
DOI
10.1101/2024.11.13.619586
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A Novel <i>C. elegans</i> Model for Tau Spreading Reveals Genes Critical for Endolysosomal Integrity and Seeded Tau AggregationDOI 10.1101/2024.11.13.619586
Alzheimer’s disease-relevant tau modifications selectively impact neurodegeneration and mitophagy in a novel <i>C. elegans</i> single-copy transgenic modelSemantic proximity
Tauopathy-associated tau modifications selectively impact neurodegeneration and mitophagy in a novel C. elegans single-copy transgenic model.Semantic proximity
Tau Clearance Reverses Neuronal Dysfunction in Both Young and Aged <i>C. elegans</i>Semantic proximity
Disruption of sphingolipid metabolism promotes tau seeding through endolysosomal membrane rigidification and ruptureSemantic proximity
Tunable Tau Expression in <i>C. elegans</i> Neurons Reveals that Early-AD Tau Phosphorylation Selectively Impacts Behavior and Mitochondrial Quality ControlSemantic proximity
Human tau compromises neuronal structural integrity in <i>C. elegans</i> promoted by age, stress and phosphorylationSemantic proximity
Progressive neurodegeneration in C. elegans model of tauopathy.Semantic proximity
Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregationSemantic proximity
Selective Disruption of Drp1-Independent Mitophagy and Mitolysosome Trafficking by an Alzheimer’s Disease Relevant Tau Modification in a Novel C. elegans ModelSemantic proximity
Intermediate Filaments Associate with Aggresome-like Structures in Proteostressed <i>C. elegans</i> Neurons and Influence Large Vesicle Extrusions as ExophersSemantic proximity
Cytoplasmic TDP-43 leads to early functional impairments without neurodegeneration in a Serotonergic Neuron-Specific <i>C. elegans</i> ModelSemantic proximity
Regulation of age-related structural integrity in neurons by protein with tau-like repeats (PTL-1) is cell autonomousSemantic proximity
Select a neighboring publication to make it the new centre.