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Tunable Tau Expression in <i>C. elegans</i> Neurons Reveals that Early-AD Tau Phosphorylation Selectively Impacts Behavior and Mitochondrial Quality Control

2026-01-28

Abstract excerpt

Tau protein accumulates myriad post-translational modifications as Alzheimer’s disease (AD) progresses, and early-disease tau modifications such as phosphorylation at threonine 231 (T231) likely play a key role in AD pathogenesis. Here, a series of “tunable tau” strains was developed in C. elegans to test the relative impact of tau pseudo-phosphorylation of T231 (T231E) compared to protein expression level as a d...

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Literature Corpus work
3082dda3-30d1-58ba-968b-23089572804a
DOI
10.64898/2026.01.26.701793
Open publication

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Tunable Tau Expression in <i>C. elegans</i> Neurons Reveals that Early-AD Tau Phosphorylation Selectively Impacts Behavior and Mitochondrial Quality ControlDOI 10.64898/2026.01.26.701793
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