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Regulation of age-related structural integrity in neurons by protein with tau-like repeats (PTL-1) is cell autonomous

5 Jun 2014

Abstract excerpt

PTL-1 is the sole homolog of the MAP2/MAP4/tau family in Caenorhabditis elegans. Accumulation of tau is a pathological hallmark of neurodegenerative diseases such as Alzheimer's disease. Therefore, reducing tau levels has been suggested as a therapeutic strategy. We previously showed that PTL-1 maintains age-related structural integrity in neurons, implying that excessive reduction in the levels of a tau-like...

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PMID: 24898126
DOI: 10.1038/srep05185

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