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Article

Tauopathy-associated tau modifications selectively impact neurodegeneration and mitophagy in a novel C. elegans single-copy transgenic model.

Molecular neurodegeneration - 9 Nov 2020

Guha Sanjib, Fischer Sarah, Johnson Gail V W, Nehrke Keith

Abstract excerpt

BACKGROUND: A defining pathological hallmark of the progressive neurodegenerative disorder Alzheimer's disease (AD) is the accumulation of misfolded tau with abnormal post-translational modifications (PTMs). These include phosphorylation at Threonine 231 (T231) and acetylation at Lysine 274 (K274) and at Lysine 281 (K281). Although tau is recognized to play a central role in pathogenesis of AD, the precise...

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Identifiers

PMID: 33168053
DOI: 10.1186/s13024-020-00410-7
PMCID: PMC7654055

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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