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Intermediate Filaments Associate with Aggresome-like Structures in Proteostressed <i>C. elegans</i> Neurons and Influence Large Vesicle Extrusions as Exophers

2022-08-05

Abstract excerpt

Under conditions of proteostasis disequilibrium, neurons can enhance intracellular and extracellular protective mechanisms to guard against neurotoxicity. In mammals, an intracellular response to severe proteostasis imbalance that results from proteosome inhibition is the formation of juxtanuclear intermediate filament-surrounded, aggregate-filled aggresomes, which sequester threatening aggregates for later dispos...

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Literature Corpus work
20bbc378-27c8-57a6-bfeb-d94ee45c8a61
DOI
10.1101/2022.08.03.501714
Open publication

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Intermediate Filaments Associate with Aggresome-like Structures in Proteostressed <i>C. elegans</i> Neurons and Influence Large Vesicle Extrusions as ExophersDOI 10.1101/2022.08.03.501714
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