Article

Human tau compromises neuronal structural integrity in <i>C. elegans</i> promoted by age, stress and phosphorylation

2025-08-01

Abstract excerpt

Tauopathies are a group of progressive neurodegenerative diseases amongst which Alzheimer’s disease is the most prevalent. They typically have a late age of onset and lead to cognitive decline. Tau is a highly soluble, intrinsically disordered microtubule binding protein that aggregates in these diseases. The mechanisms by which age-associated changes alter tau functionality and compromise neuronal structural inte...

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Literature Corpus work: b6644ecd-f6b1-59a3-ac98-b296a6f33933
DOI: 10.1101/2025.08.01.668095

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