Article

Disruption of sphingolipid metabolism promotes tau seeding through endolysosomal membrane rigidification and rupture

2024-10-25

Abstract excerpt

Endolysosomal dysfunction is a hallmark of Alzheimer’s disease (AD) and related tauopathies, yet underlying mechanisms remain poorly understood. This study investigates the role of sphingolipid metabolism in maintaining endolysosomal membrane integrity and its impact on tau aggregation and toxicity in Caenorhabditis elegans and human cell culture models. Fluorescence recovery after photobleaching and C-Laurdan dy...

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Literature Corpus work: 9da95ca8-aae7-5636-9027-a93ef6a19fd0
DOI: 10.1101/2024.10.24.619578

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