Article

Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation

2019-05-15

Abstract excerpt

<h4>ABSTRACT</h4> Intercellular propagation of protein aggregation is emerging as a key mechanism in the progression of several neurodegenerative diseases, including Alzheimer’s Disease and frontotemporal dementia. However, we lack a systematic understanding of the cellular path-ways controlling prion-like propagation. To uncover such pathways, we performed CRISPR interference (CRISPRi) screens in a human cell-ba...

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Literature Corpus work: 7d6bd733-1754-5832-9ada-178dc1108833
DOI: 10.1101/637785

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