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Selective Disruption of Drp1-Independent Mitophagy and Mitolysosome Trafficking by an Alzheimer’s Disease Relevant Tau Modification in a Novel C. elegans Model

2021-11-29

Abstract excerpt

<title>Abstract</title> <bold>Background:</bold> Accumulation of inappropriately phosphorylated tau into neurofibrillary tangles (NFT) is a defining feature of Alzheimer’s Disease (AD), with specific epitopes such as Tau pT231 emerging early in the development of tau pathology. Previously, we demonstrated that a phosphomimetic mutant (T231E) of human tau drove the loss of neuronal function and structural integ...

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Literature Corpus work: 5f7e5b95-e9dc-5c97-a400-623fa6598f35
DOI: 10.21203/rs.3.rs-1096882/v1

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