Article

Cytoplasmic TDP-43 leads to early functional impairments without neurodegeneration in a Serotonergic Neuron-Specific C. elegans Model

2025-07-31

Abstract excerpt

TDP-43 proteinopathies, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), are marked by the pathological cytoplasmic accumulation of TAR DNA-binding protein 43 (TDP-43), leading to progressive neuronal dysfunction and degeneration. To investigate the early functional consequences of TDP-43 mislocalization, we generated Caenorhabditis elegans models expressing either wild-type human TD...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d1212313-b273-5041-b5b4-490bafc8e876
DOI: 10.1101/2025.07.30.667669

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cytoplasmic TDP-43 leads to early functional impairments without neurodegeneration in a Serotonergic Neuron-Specific C. elegans ModelDOI 10.1101/2025.07.30.667669Read

Phosphorylation Promotes Neurotoxicity in aCaenorhabditis elegansModel of TDP-43 ProteinopathySemantic proximity Read

Neurotoxic effects of TDP-43 overexpression in C. elegans.Semantic proximity Read

Mutant TDP-43 and FUS cause age-dependent paralysis and neurodegeneration in C. elegans.Semantic proximity Read

Transgenic TDP-43 and endogenous TDP-1 Caenorhabditis elegans ALS models show motor deficits and age-dependent neurodegenerationSemantic proximity Read

Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity.Semantic proximity Read

Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease modelsSemantic proximity Read

Rebalancing the motor circuit restores movement in a Caenorhabditis elegans model for TDP-43-toxicitySemantic proximity Read

A Drosophila model for TDP-43 proteinopathySemantic proximity Read

Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficitsSemantic proximity Read

Human TDP-43 overexpression in zebrafish motor neurons triggers MND-like phenotypes through gain-of-function mechanismSemantic proximity Read

Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy.Semantic proximity Read

Drosophila Answers to TDP-43 ProteinopathiesSemantic proximity Read

Cytoplasmic TDP-43 leads to early functional impairments without neurodegeneration in a Serotonergic Neuron-Specific <i>C. elegans</i> Model

Abstract excerpt

Topics

Identifiers and source

Related research