Article

Alzheimer’s disease-relevant tau modifications selectively impact neurodegeneration and mitophagy in a novel <i>C. elegans</i> single-copy transgenic model

2020-02-13

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> A defining pathological hallmark of the progressive neurodegenerative disorder Alzheimer’s disease (AD) is the accumulation of misfolded tau with abnormal post-translational modifications (PTMs). These include phosphorylation at Threonine 231 (T231) and acetylation at Lysine 274 (K274) and at Lysine 281 (K281). Although tau is recognized to play a central role in pathogenesi...

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Literature Corpus work: c8d954f9-c982-5c55-9fac-769cb14fd9a7
DOI: 10.1101/2020.02.12.946004

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