Article
Progressive neurodegeneration in C. elegans model of tauopathy.
Neurobiology of disease - 1 Nov 2005
Miyasaka Tomohiro, Ding Zhen, Gengyo-Ando Keiko, Oue Miho, Yamaguchi Haruyasu, Mitani Shohei, Ihara Yasuo
Abstract excerpt
Discovery of various mutations in the tau gene among frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) families suggests gain-of-toxic function of wild-type or mutant tau as the mechanism for extensive neuronal loss. We thus generated transgenic nematode (Caenorhabditis elegans) expressing wild-type or mutant (P301L and R406W) tau in the touch (mechanosensory) neurons. Whereas the worm...
Topics
- Animals
- Animals, Genetically Modified
- Caenorhabditis elegans
- Disease Models, Animal
- Glycogen Synthase Kinase 3
- Glycogen Synthase Kinase 3 beta
- HSP70 Heat-Shock Proteins
- Immunohistochemistry
- Mechanoreceptors
- Microscopy, Electron, Transmission
- Microtubules
- Mutation
- Nerve Degeneration