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Article

Progressive neurodegeneration in C. elegans model of tauopathy.

Neurobiology of disease - 1 Nov 2005

Miyasaka Tomohiro, Ding Zhen, Gengyo-Ando Keiko, Oue Miho, Yamaguchi Haruyasu, Mitani Shohei, Ihara Yasuo

Abstract excerpt

Discovery of various mutations in the tau gene among frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) families suggests gain-of-toxic function of wild-type or mutant tau as the mechanism for extensive neuronal loss. We thus generated transgenic nematode (Caenorhabditis elegans) expressing wild-type or mutant (P301L and R406W) tau in the touch (mechanosensory) neurons. Whereas the worm...

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PMID: 16242642
DOI: 10.1016/j.nbd.2005.03.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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