Article

Alzheimer’s disease-associated genotypes differentially influence chronic evoked seizure outcomes and antiseizure medicine activity in aged mice

2024-10-07

Abstract excerpt

<h4>Structured Abstract</h4> <h4>INTRODUCTION</h4> Alzheimer’s disease (AD) patients are at greater risk of focal seizures than similarly aged adults; these seizures, left untreated, may worsen functional decline. Older people with epilepsy generally respond well to antiseizure medications (ASMs). However, whether specific ASMs can differentially control seizures in AD is unknown. The corneal kindled mouse model...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cee763c6-f6a2-510b-9c9a-23b13fa2a5bb
DOI: 10.1101/2024.10.06.616921

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Alzheimer’s disease-associated genotypes differentially influence chronic evoked seizure outcomes and antiseizure medicine activity in aged miceDOI 10.1101/2024.10.06.616921Read

Alzheimer's disease-associated genotypes differentially influence chronic evoked seizure outcomes and antiseizure medicine efficacy in aged mice.Semantic proximity Read

Loss of presenilin 2 age-dependently alters susceptibility to acute seizures and kindling acquisition.Semantic proximity Read

Alzheimer's Disease and Epilepsy: A Perspective on the Opportunities for Overlapping Therapeutic Innovation.Semantic proximity Read

Chronic evoked seizures in young pre-symptomatic APP/PS1 mice induce serotonin changes and accelerate onset of Alzheimer’s disease-related neuropathologySemantic proximity Read

Chronic Seizures Induce Sex-Specific Cognitive Deficits with Loss of Presenilin 2 FunctionSemantic proximity Read

Antiseizure drug efficacy and tolerability in established and novel drug discovery seizure models in outbred vs inbred miceSemantic proximity Read

A mouse model of Alzheimer's disease displays increased susceptibility to kindling and seizure-associated death.Semantic proximity Read

Loss of presenilin 2 function age-dependently increases susceptibility to kainate-induced acute seizures and blunts hippocampal kainate-type glutamate receptor expressionSemantic proximity Read

Leveraging preclinical models for the development of Alzheimer disease therapeutics.Semantic proximity Read

DBA/2J genetic background exacerbates spontaneous lethal seizures but lessens amyloid deposition in a mouse model of Alzheimer's disease.Semantic proximity Read

A perfect storm: Converging paths of epilepsy and Alzheimer's dementia intersect in the hippocampal formation.Semantic proximity Read

PAC – A novel translational concordance framework identifies preclinical seizure models with highest predictive validity for clinical focal onset seizuresSemantic proximity Read