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Article

Antiseizure drug efficacy and tolerability in established and novel drug discovery seizure models in outbred vs inbred mice

5 Aug 2020

Abstract excerpt

OBJECTIVE: Initial identification of new investigational drugs for the treatment of epilepsy is commonly conducted in well-established mouse acute and chronic seizure models: for example, maximal electroshock (MES), 6 Hz, and corneal kindling. Comparison of the median effective dose (ED50) of approved antiseizure drugs (ASDs) vs investigational agents in these models provides evidence of their potential for...

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PMID: 32757210
DOI: 10.1111/epi.16624

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