Article

Chronic Seizures Induce Sex-Specific Cognitive Deficits with Loss of Presenilin 2 Function

2021-12-17

Abstract excerpt

Patients with early-onset Alzheimer’s disease (EOAD) are at elevated risk for seizures, including patients with presenilin 2 (PSEN2) variants. Like people with epilepsy, uncontrolled seizures may worsen cognitive function in AD. While the relationship between seizures and amyloid beta accumulation has been more thoroughly investigated, the role of other drivers of seizure susceptibility in EOAD remain relatively u...

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Literature Corpus work: 652b5252-b86b-526f-8409-171c37fc1afd
DOI: 10.1101/2021.12.16.472840

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