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Article

A perfect storm: Converging paths of epilepsy and Alzheimer's dementia intersect in the hippocampal formation.

Epilepsia - 1 Jan 2011

Noebels Jeffrey

Abstract excerpt

Seizures in the human temporal lobe transiently impair cognition and steadily damage hippocampal circuitry, leading to progressive memory loss. Similarly, the toxic accumulation of Aβ peptides underlying Alzheimer's disease (AD) triggers synaptic degeneration, circuit remodeling, and abnormal synchronization within the same networks. Because neuronal hyperexcitability amplifies the synaptic release of Aβ,...

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Source

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Identifiers

PMID: 21214538
DOI: 10.1111/j.1528-1167.2010.02909.x
PMCID: PMC3058398

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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