Article

Loss of presenilin 2 function age-dependently increases susceptibility to kainate-induced acute seizures and blunts hippocampal kainate-type glutamate receptor expression

2025-09-11

Abstract excerpt

Presenilin 2 (PSEN2) variants increase risk of Alzheimer’s disease (AD) and unprovoked seizures. Yet, age-related PSEN2 contributions to seizure susceptibility are understudied. Critically, PSEN proteolytic capacity may regulate hippocampal kainate-type glutamate receptor (KARs) availability. Kainic acid (KA) is a KAR agonist that evokes severe seizures in mice. We hypothesized that PSEN2 knockout (KO) mice would...

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Literature Corpus work: 240682ff-20d5-5a3b-aa5d-754fb5654913
DOI: 10.1101/2025.09.09.675240

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