Article
Leveraging preclinical models for the development of Alzheimer disease therapeutics.
Nature reviews. Drug discovery - 1 Jul 2020
Scearce-Levie Kimberly, Sanchez Pascal E, Lewcock Joseph W
Abstract excerpt
A large number of mouse models have been engineered, characterized and used to advance biomedical research in Alzheimer disease (AD). Early models simply damaged the rodent brain through toxins or lesions. Later, the spread of genetic engineering technology enabled investigators to develop models of familial AD by overexpressing human genes such as those encoding amyloid precursor protein (APP) or presenilins...
Topics
- Alzheimer Disease
- Animals
- Biomarkers
- Disease Models, Animal
- Drug Development
- Drug Evaluation, Preclinical
- Genetic Predisposition to Disease
- Humans
- Mice
- Mutation
- Risk Factors