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Article

Loss of presenilin 2 age-dependently alters susceptibility to acute seizures and kindling acquisition.

Neurobiology of disease - 1 Mar 2020

Beckman Megan, Knox Kevin, Koneval Zachery, Smith Carole, Jayadev Suman, Barker-Haliski Melissa

Abstract excerpt

Patients with Alzheimer's disease (AD) experience seizures at higher rates than the general population of that age, suggesting an underexplored role of hyperexcitability in AD. Genetic variants in presenilin (PSEN) 1 and 2 genes lead to autosomal dominant early-onset AD (ADAD); patients with PSEN gene variants also report seizures. Pharmacological control of seizures in AD may be disease-modifying. Preclinical...

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Identifiers

PMID: 31862541
DOI: 10.1016/j.nbd.2019.104719
PMCID: PMC7462087

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