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Article

DBA/2J genetic background exacerbates spontaneous lethal seizures but lessens amyloid deposition in a mouse model of Alzheimer's disease.

PloS one - 1 Jan 2015

Jackson Harriet M, Onos Kristen D, Pepper Keating W, Graham Leah C, Akeson Ellen C, Byers Candice, Reinholdt Laura G, Frankel Wayne N, Howell Gareth R

Abstract excerpt

Alzheimer's disease (AD) is a leading cause of dementia in the elderly and is characterized by amyloid plaques, neurofibrillary tangles (NFTs) and neuronal dysfunction. Early onset AD (EOAD) is commonly caused by mutations in amyloid precursor protein (APP) or genes involved in the processing of APP including the presenilins (e.g. PSEN1 or PSEN2). In general, mouse models relevant to EOAD recapitulate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25933409
DOI: 10.1371/journal.pone.0125897
PMCID: PMC4416920

Genes

APP
PSEN1
PSEN2

Provenance

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