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Article

Alzheimer's Disease and Epilepsy: A Perspective on the Opportunities for Overlapping Therapeutic Innovation.

Neurochemical research - 1 Aug 2021

Lehmann Leanne, Lo Alexandria, Knox Kevin M, Barker-Haliski Melissa

Abstract excerpt

Early-onset Alzheimer's disease (AD) is associated with variants in amyloid precursor protein (APP) and presenilin (PSEN) 1 and 2. It is increasingly recognized that patients with AD experience undiagnosed focal seizures. These AD patients with reported seizures may have worsened disease trajectory. Seizures in epilepsy can also lead to cognitive deficits, neuroinflammation, and neurodegeneration. Epilepsy is...

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Identifiers

PMID: 33929683
DOI: 10.1007/s11064-021-03332-y
PMCID: PMC8254705

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