Article

PAC – A novel translational concordance framework identifies preclinical seizure models with highest predictive validity for clinical focal onset seizures

2025-04-08

Abstract excerpt

<h4>ABSTRACT/SUMMARY</h4> <h4>Objective</h4> Central to the development of novel antiseizure medications (ASMs) is testing of anticonvulsant activity in preclinical models. While various well-established models exist, their predictive validity across the spectrum of clinical epilepsies has been less clear. We sought to establish the translational concordance of commonly used preclinical models to define models w...

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Literature Corpus work: 726b7b0a-6f00-5b87-8c10-9cb20e940b8b
DOI: 10.1101/2025.04.04.647239

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