Article

Chronic evoked seizures in young pre-symptomatic APP/PS1 mice induce serotonin changes and accelerate onset of Alzheimer’s disease-related neuropathology

2023-01-05

Abstract excerpt

<h4>Objective</h4> People with early-onset Alzheimer’s disease (AD) are at elevated seizure risk. Further, chronic seizures in pre-symptomatic stages may disrupt serotonin pathway-related protein expression, precipitating the onset of AD-related pathology and burden of neuropsychiatric comorbidities. <h4>Methods</h4> 2-3-month-old APP/PS1, PSEN2-N141I, and transgenic control mice were sham or corneal kindled for...

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Literature Corpus work: ef5a0319-d25c-540b-8d8f-b98f0758698b
DOI: 10.1101/2023.01.05.522897

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