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Article

Alzheimer's disease-associated genotypes differentially influence chronic evoked seizure outcomes and antiseizure medicine efficacy in aged mice.

Journal of Alzheimer's disease : JAD - 1 Jul 2025

Knox Kevin M, Davidson Stephanie, Lehmann Leanne M, Skinner Erica, Lo Alexandria, Jayadev Suman, Barker-Haliski Melissa

Abstract excerpt

BackgroundAlzheimer's disease (AD) patients are at greater risk of focal seizures than similarly aged adults, which may accelerate cognitive decline. Older people with epilepsy generally respond well to antiseizure medications (ASMs). However, whether specific ASMs can differentially control seizures in AD is unknown. The corneal kindled model of chronic seizures allows for precisely timed drug administration...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40458037
DOI: 10.1177/13872877251343321
PMCID: PMC12282399

Genes

APP
PSEN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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