Kinetic proofreading as a mechanism for transcriptional specificity in living human cells

Abstract excerpt

How target genes selectively respond to their specific transcription factors (TF) amid the vast excess of non-specific TFs in the nucleus remains a fundamental question in gene regulation. Here, we develop an integrated single-molecule imaging framework to quantitatively link TF dynamics with nascent transcription kinetics at endogenous gene loci to address the transcription factor specificity. Using endogenously...

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• CAR-T cell therapy research
• Protein Degradation and Inhibitors
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

cc5a6940-7cbf-5961-8042-ddc6cac321b4

DOI

10.64898/2026.03.17.711757