A Cooperative Mechanism of Eukaryotic Transcription Factor Target Search

Abstract excerpt

<h4>ABSTRACT</h4> Rapid gene activation requires transcription factors (TFs) to locate their target motifs within vast genomes. In bacteria, TF target search is accelerated by combining 3D diffusion with 1D sliding, called facilitated diffusion, yet whether eukaryotic TFs rely on similar strategies has remained unresolved due to the lack of direct measurements in living cells. Here, we directly visualize eukaryot...

Topics

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• Adaptor Proteins, Signal Transducing
• Intrinsically Disordered Proteins
• Protein Domains
• Protein Interaction Domains and Motifs
• Protein Interaction Maps
• RNA-Binding Proteins
• RNA Polymerase II
• Transcriptional Elongation Factors

Identifiers and source

Literature Corpus work

760a3d38-f391-5057-85ee-06c576e7d4f8

DOI

10.64898/2026.03.09.709760