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Synthetic analysis of chromatin tracing and live-cell imaging indicates pervasive spatial coupling between genes

2022-07-08

Abstract excerpt

The role of the spatial organization of chromosomes in directing transcription remains an outstanding question in gene regulation. Here, we analyze two recent single-cell imaging methodologies applied across hundreds of genes to systematically analyze the contribution of chromosome conformation to transcriptional regulation. Those methodologies are: 1) single-cell chromatin tracing with super-resolution imaging in...

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Literature Corpus work
e94fa207-63fc-5260-80d5-90808fe0a1e1
DOI
10.1101/2022.07.07.499202
Open publication

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Synthetic analysis of chromatin tracing and live-cell imaging indicates pervasive spatial coupling between genesDOI 10.1101/2022.07.07.499202
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