Article

Interrogation of the Dynamic Properties of Higher-Order Heterochromatin Using CRISPR/dCas9

2021-06-07

Abstract excerpt

<h4>ABSTRACT</h4> Eukaryotic chromosomes feature large regions of compact, repressed heterochromatin hallmarked by Heterochromatin Protein 1 (HP1). HP1 proteins play multi-faceted roles in shaping heterochromatin, and in cells, HP1 tethering to individual gene promoters leads to epigenetic modifications and silencing. However, emergent properties of HP1 at supranucleosomal scales remain difficult to study in cell...

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Literature Corpus work: 62ab2d5c-6314-5747-940c-bf1b51760807
DOI: 10.1101/2021.06.06.447300

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