Article

Discovery of a Cellular Mechanism Regulating Transcriptional Noise

2020-06-30

Abstract excerpt

Stochastic fluctuations in gene expression (‘noise’) are often considered detrimental but, in other fields, fluctuations are harnessed for benefit (e.g., ‘dither’ or amplification of thermal fluctuations to accelerate chemical reactions). Here, we find that DNA base-excision repair amplifies transcriptional noise, generating increased cellular plasticity and facilitating reprogramming. The DNA-repair protein Apex1...

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Identifiers and source

Literature Corpus work: 64bd7b48-f40d-5561-9659-e44317626305
DOI: 10.1101/2020.06.29.128439

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