Article

Dynamic transcription pre-initiation complex assembly governs initiation efficiency

2025-05-12

Abstract excerpt

Transcription initiation is a highly regulated process that determines gene expression outcomes 1,2 , yet the dynamics of initiation and the mechanisms governing efficiency remain poorly understood. Here, we combine endogenous tagging of human RNA polymerase II (Pol II) and TFIID with simultaneous live-cell, multi-color single-molecule imaging to quantitatively map Pol II behavior during transcription initiation...

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Literature Corpus work: 085226a5-0bb0-5900-a6fa-fd66f73606ea
DOI: 10.1101/2025.05.07.652662

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