Article

RNA polymerase II initiation factors show different dynamic behaviour upon induced transcription in live cells

2025-12-21

Abstract excerpt

Transcription by RNA polymerase II (Pol II) requires the ordered action of general transcription factors (GTFs) forming the pre-initiation complex (PIC). How these events unfold kinetically remains unclear. Upon transcription activation, we observe coordinated recruitment of Pol II and GTFs together with chromatin decompaction. Pol II and its Ser5-phosphorylated form accumulate and persist at promoters, whereas TF...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b2e4ee31-e888-5aa0-81b5-b180a1ea179f
DOI: 10.64898/2025.12.19.695093

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

RNA polymerase II initiation factors show different dynamic behaviour upon induced transcription in live cellsDOI 10.64898/2025.12.19.695093Read

Dynamic transcription pre-initiation complex assembly governs initiation efficiencySemantic proximity Read

The kinetic landscape of human transcription factorsSemantic proximity Read

Single-molecule microscopy reveals that TFIIE subunits dynamically interact with preinitiation complexes in a manner controlled by TFIIHSemantic proximity Read

Transcription initiation by human RNA polymerase II visualized at single-molecule resolution.Semantic proximity Read

Multi-timescale PTM architecture in human RNA polymerase IISemantic proximity Read

Release of human TFIIB from actively transcribing complexes is triggered upon synthesis of 7 nt and 9 nt RNAsSemantic proximity Read

Multi-omics and biochemical reconstitution reveal CDK7-dependent mechanisms controlling RNA polymerase II function at gene 5’- and 3’-endsSemantic proximity Read

LIET Model: Capturing the kinetics of RNA polymerase from loading to terminationSemantic proximity Read

Crosstalk between mRNA 3' end processing and transcription initiation.Semantic proximity Read

A ubiquitous disordered protein interaction module orchestrates transcription elongation.Semantic proximity Read

High-resolution mapping of human RNA polymerase III reveals transcription termination as a rate-limiting stepSemantic proximity Read

Cluster size determines internal structure of transcription factories in human cellsSemantic proximity Read